DESCRIPTION
PCE (erythromycin particles in tablets) is an antibacterial
product containing specially coated erythromycin
base particles for oral
administration. The coating protects the antibiotic
from the inactivating effects of gastric acidity and permits efficient
absorption of the
antibiotic in the
small intestine. PCE is available in two strengths containing either
333 mg or 500 mg
of erythromycin
base. PCE 500 mg tablets
contain no synthetic
dyes or artificial
colors.
Erythromycin is produced by a strain
of Saccharopolyspora erythraea (formerly Streptomyces ervthraeus)
and belongs to the macrolide
group of antibiotics.
It is basic and readily
forms salts with acids. Erythromycin is a white
to off-white powder, slightly soluble
in water, and soluble in alcohol,
chloroform, and ether. Erythromycin is known chemically as [(3R*,4S*,5S*,6R*,7R*,9R*,11R*,
12R*,13S*, methyl-a-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,
13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-13-D-xylo-hexopyranosyl]
oxy]oxacyclotetradecane-2,10-dione. The molecular formula
is C37H67NO13, and the molecular
weight is 733.94.
Inactive Ingredients:
PCE 333 mg tablets:
Cellulosic polymers, citrate
ester, colloidal silicon
dioxide, D&C Red No. 30, hydrogenated vegetable
oil wax, lactose, magnesium
stearate, microcrystalline
cellulose, povidone,
propylene glycol, sodium
starch glycolate, stearic
acid and vanillin.
PCE 500 mg tablets:
Cellulosic polymers, citrate
ester, colloidal silicon
dioxide, crospovidone, hydrogenated vegetable
oil wax, iron oxide, microcrystalline
cellulose, polyethylene
glycol, povidone, propylene glycol, stearic acid,
talc, titanium dioxide
and vanillin.
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