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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Erythromycin PCE



DESCRIPTION

PCE (erythromycin particles in tablets) is an antibacterial product containing specially coated erythromycin base particles for oral administration. The coating protects the antibiotic from the inactivating effects of gastric acidity and permits efficient absorption of the antibiotic in the small intestine. PCE is available in two strengths containing either 333 mg or 500 mg of erythromycin base. PCE 500 mg tablets contain no synthetic dyes or artificial colors.

Erythromycin is produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces ervthraeus) and belongs to the macrolide group of antibiotics. It is basic and readily forms salts with acids. Erythromycin is a white to off-white powder, slightly soluble in water, and soluble in alcohol, chloroform, and ether. Erythromycin is known chemically as [(3R*,4S*,5S*,6R*,7R*,9R*,11R*, 12R*,13S*, methyl-a-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11, 13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-13-D-xylo-hexopyranosyl] oxy]oxacyclotetradecane-2,10-dione. The molecular formula is C37H67NO13, and the molecular weight is 733.94.

Inactive Ingredients:
PCE 333 mg tablets: Cellulosic polymers, citrate ester, colloidal silicon dioxide, D&C Red No. 30, hydrogenated vegetable oil wax, lactose, magnesium stearate, microcrystalline cellulose, povidone, propylene glycol, sodium starch glycolate, stearic acid and vanillin.
PCE 500 mg tablets: Cellulosic polymers, citrate ester, colloidal silicon dioxide, crospovidone, hydrogenated vegetable oil wax, iron oxide, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, stearic acid, talc, titanium dioxide and vanillin.




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