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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (E's) » Etodolac



DESCRIPTION

Lodine® XL (etodolac extended-release tablets) contains etodolac in an extended-release formulation. Etodolac is a pyranocarboxylic acid, chemically designated as (±) 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid.

The empirical formula is C17H21NO3. The molecular weight of the base is 287.37. It has a pKa of 4.65 and an n-octanol:water partition coefficient of 11.4 at pH 7.4. Etodolac is a white crystalline compound, insoluble in water, but soluble in alcohols, chloroform, dimethyl sulfoxide, and aqueous polyethylene glycol.

The inactive ingredients are dibasic sodium phosphate, ethylcellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, polyethylene glycol, and titanium dioxide. In addition, the 400 mg tablets also contain FD&C Red #40, and FD&C Yellow #6 as color additives and polysorbate 80. The 600 mg tablets also contain hydroxypropyl cellulose and iron oxide.

Lodine XL is available in 400 and 600 mg tablets, for oral administration.





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