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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (F's) » Flunisolide (Nasal Spray)



DESCRIPTION

NASALIDE® (flunisolide) nasal spray is intended for administration as a spray to the nasal mucosa. Flunisolide, the active component of NASALIDE nasal spray, is an anti-inflammatory steroid with the chemical name: 6a-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone (USAN).

Flunisolide is a white to creamy white crystalline powder with a molecular weight of 434.49 and molecular formula of C24H31FO6. It is soluble in acetone, sparingly soluble in chloroform, slightly soluble in methanol, and practically insoluble in water. It has a melting point of about 245 C.

Each 25 mL spray bottle contains flunisolide 6.25 mg (0.25 mg/mL) in a solution of propylene glycol, polyethylene glycol 3350, citric acid, sodium citrate, butylated hydroxyanisole, edetate disodium, benzalkonium chloride and purified water, with NaOH and/or HCl added to adjust the pH to a target of 5.3.

After initial priming (5 to 6 sprays), each spray of the unit delivers a metered droplet spray of 100 mg formulation containing 25 mcg of flunisolide. The size of the droplets produced by the unit is in excess of 8 microns to facilitate deposition on the nasal mucosa. The contents of one nasal spray bottle deliver 200 sprays.





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