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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (G's) » Glucagon



DESCRIPTION

Glucagon for Injection (rDNA origin) is a polypeptide hormone identical to human glucagon that increases blood glucose and relaxes smooth muscle of the gastrointestinal tract. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagon.

Glucagon is a single- chain polypeptide that contains 29 amino acid residues and has a molecular weight of 3,483.

The empirical formula is C153H225N43O49S. The primary sequence of glucagon is shown below.

Crystalline glucagon is a white to off- white powder. It is relatively insoluble in water but is soluble at a pH of less than 3 or more than 9.5.

Glucagon is available for use intravenously, intramuscularly, or subcutaneously in a kit that contains a vial of sterile glucagon and a syringe of sterile diluent. The vial contains 1 mg (1 unit) of glucagon and 49 mg of lactose. Hydrochloric acid may have been added during manufacture to adjust the pH of the glucagon.1 One International Unit of glucagon is equivalent to 1 mg of glucagon. The diluent syringe contains 12 mg/ mL of glycerin, water for injection, and hydrochloric acid.





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