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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (B's) » Bisoprolol and Hydrochlorothiazide


Bisoprolol fumarate; hydrochlorothiazide is indicated for the treatment of hypertension. It combines two antihypertensive agents in a once-daily dosage; a synthetic beta1-selective (cardioselective) adrenoceptor blocking agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).

Bisoprolol fumarate is chemically described as (± )-1-(4-((2-(1-Methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol (E)-2-butenedioate (2:1) (salt). It possesses an asymmetric carbon atom in its structure and is provided as a racemic mixture. The S(-) enantiomer is responsible for most of the beta-blocking activity. Its empirical formula is (C18H31NO4)2C4H4O4 and it has a molecular weight of 766.97.

Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.

Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. It is a white, or practically white, practically odorless crystalline powder. It is slightly soluble in water, sparingly soluble in dilute sodium hydroxide solution, freely soluble in n-butylamine and dimethylformamide, soluble in methanol, and insoluble in ether, chloroform, and dilute mineral acids. Its empirical formula is C7H8ClN3O4S2 and it has a molecular weight of 297.73.

Each bisoprolol fumarate; HCTZ 2.5 mg/6.25 mg tablet for oral administration contains bisoprolol fumarate 2.5 mg, hydrochlorothiazide 6.25 mg.

Each bisoprolol fumarate; HCTZ 5 mg/6.25 mg tablet for oral administration contains bisoprolol fumarate 5 mg, hydrochlorothiazide 6.25 mg

Each bisoprolol fumarate; HCTZ 10 mg/6.25 mg tablet for oral administration contains bisoprolol fumarate 10 mg, hydrochlorothiazide 6.25 mg

Inactive ingredients include colloidal silicon dioxide, corn starch, dibasic calcium phosphate, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, and titanium dioxide. the 5 mg/6.25 mg tablet also contains red and yellow iron oxide. the 2.5 mg/6.25 mg tablet also contains crospovidone, pregelatinized starch and yellow iron oxide.


CATEGORIES: Hypertension, essential; FDA Class 1S ("Standard Review"); FDA Approved 1993 Mar; Pregnancy Category C; Top 200 Drugs

FDA Drug Classes: Antihypertensives


BRAND NAMES: Concor Plus; Concor Plus Forte; Ziac; Ziak
(Foreign Brand names outside U.S. in italics)

Concor Plus (Austria; Switzerland)
Concor Plus Forte (Austria)
Ziak (South-Africa)

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