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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Ciprofloxacin



DESCRIPTION

Oral

Ciprofloxacin hydrochloride tablets and oral suspension are synthetic broad spectrum antimicrobial agents for oral administration. Ciprofloxacin hydrochloride, a fluoroquinolone is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluora-1, 4-dihydro-4-oxa-7-(1-piperazinyl)-3-quinolinecarboxylic acid. It is a faintly yellowish to light yellow crystalline substance with a molecular weight of 385.8. Its empirical formula is C17H18FN3O3·HCl·H2O.

Ciprofloxacin is 1-cyclopropyl-6-fluoro-1, 4-drhydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C17H18FN3O3 and its molecular weight is 331.4 It is a faintly yellowish to light yellow crystalline substance.

Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position.

Cipro film-coated tablets are available in 100-mg, 250-mg, 500-mg and 750-mg (ciprofloxacin equivalent) strengths. The inactive ingredients are starch, microcrystalline cellulose, silicon dioxide, crospovidone, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, polyethylene glycol and water.

Ciprofloxacin HCl oral suspension is available in 5% (5 g ciprofloxacin in 100 ml) and 10% (10 g ciprofloxacin in 100 ml) strengths. Ciprofloxacin HCl oral suspension is a white to slightly yellowish suspension with strawberry flavor which may contain yellow-orange droplets. It is composed of ciprofloxacin microcapsules and diluent which are mixed prior to dispensing (See PATIENT PACKAGE INSERT). The components of the suspension have the following compositions:

Microcapsules: Ciprofloxacin, polyvinylpyrrolidone, methacrylic acid copolymer, hydroxypropyl methylcellulose, magnesium stearate and Polysorbate 20.

Diluent: Medium-chain triglycerides, sucrose, lecithin, water, and strawberry flavor.

I.V.

Ciprofloxacin is a synthetic broad-spectrum antimicrobial agent for intravenous (I.V.) administration. Ciprofloxacin, a fluoroquinolone, is 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, its empirical formula is C17H18FN3O3.

Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 331.4. It is soluble in dilute (0 1N) hydrochloric acid and is practically insoluble in water and ethanol. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. Cipro I.V. solutions are available as sterile 1.0% aqueous concentrates, which are intended for dilution prior to administration, and as 0.2% ready-for-use infusion solutions in 5% Dextrose injection. All formulas contain lactic acid as a solubilizing agent and hydrochloric acid for pH adjustment. The pH range for the 1.0% aqueous concentrates in vials is 3.3 to 3.9. The pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6.

The plastic container is fabricated from a specially formulated polyvinyl chloride. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

CATEGORIES, BRAND NAMES

CATEGORIES: Cystitis; Diarrhea, infectious; Gonorrhea; Infection, bone; Infection, gastrointestinal tract; Infection, intra-abdominal; Infection, joint; Infection, lower respiratory tract; Infection, sinus; Infection, skin and skin structures; Infection, upper respiratory tract; Infection, urinary tract; Pneumonia, nosocomial; Prostatitis, chronic; Typhoid; Pregnancy Category C; FDA Approved 1987 Oct; Top 200 Drugs; WHO Formulary

FDA Drug Classes: Ocular Anti-Infective; Quinolones/Derivatives

BRAND NAMES:

BRAND NAMES: Alcon Cilox; Bacquinor; Baflox; Baycip; Bernoflox; Bi-Cipro; Cetraxal; Ciflox; Cifloxin; Cifran; Cilab; Ciloxan; Cimogal; Ciplox; Ciplus; Ciprecu; Ciprinol; Cipro; Ciprobay; Ciprobay Uro; Ciprobid; Ciprobiotic; Ciprocinol; Ciprodar; Ciproflox; Ciprogis; Ciprok; Ciprolin; Ciprolon; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Ciproxina; Ciproxine; Ciprowin; Ciriax; Citopcin; Cixan; Corsacin; Cosflox; Cycin; Cyprobay; Eni; Fimoflox; Italnik; Ipiflox; Kenzoflex; Loxan; Medociprin; Mitroken; Nivoflox; Probiox; Proflaxin; Proflox; Proksi 250; Proksi 500; Quinolid; Quintor; Rancif; Roxytal; Septicide; Sophixin Ofteno; Spitacin; Superocin; Unex; Uniflox; Zumaflox
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Alcon Cilox (Indonesia)
Bacquinor (Indonesia)
Baflox (Colombia)
Baycip (Spain)
Bernoflox (Indonesia)
Bi-Cipro (India)
Cetraxal (Guatemala; Honduras; Panama; Spain)
Ciflox (France)
Cifloxin (Thailand)
Cifran (India)
Cilab (Thailand)
Cimogal (Mexico)
Ciplox (Bahrain; Benin; Burkina-Faso; Cyprus; Egypt; Ethiopia; Gambia; Ghana; Guinea; India; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Tanzania; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Ciplus (Korea)
Ciprecu (Ecuador)
Ciprinol (Bulgaria; Hungary)
Ciprobay (Bahrain; Bulgaria; Cyprus; Czech-Republic; Egypt; Germany; Hungary; Iran; Iraq; Israel; Jordan; Korea; Kuwait; Lebanon; Libya; Malaysia; Oman; Philippines; Qatar; Republic-Of-Yemen; Saudi-Arabia; South-Africa; Syria; Thailand; United-Arab-Emirates)
Ciprobay Uro (Germany)
Ciprobid (Bahrain; Benin; Burkina-Faso; Cyprus; Egypt; Ethiopia; Gambia; Ghana; Guinea; India; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Tanzania; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Ciprobiotic (Dominican-Republic)
Ciprocinol (Bulgaria)
Ciprodar (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Ciproflox (Bulgaria; Mexico)
Ciprogis (Israel)
Ciprok (Spain)
Ciprolin (Peru)
Ciprolon (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Cipromycin (Greece)
Ciproquinol (Portugal)
Ciproxan (Japan)
Ciproxin (Australia; Austria; Benin; Burkina-Faso; Denmark; England; Ethiopia; Finland; Gambia; Ghana; Greece; Guinea; Hong-Kong; Indonesia; Ireland; Israel; Italy; Ivory-Coast; Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Netherlands; New-Zealand; New-Zealand; Niger; Nigeria; Norway; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Sweden; Switzerland; Taiwan; Tanzania; Tunia; Uganda; Zambia; Zimbabwe)
Ciproxina (Costa-Rica; Dominican-Republic; Ecuador; El-Salvador; Guatemala; Honduras; Mexico; Nicaragua; Panama; Portugal)
Ciproxine (Belgium)
Ciprowin (India)
Ciriax (Peru)
Citopcin (Korea)
Cixan (Colombia)
Corsacin (Indonesia)
Cosflox (India)
Cycin (Korea)
Eni (Mexico)
Fimoflox (Indonesia)
Italnik (Mexico)
Ipiflox (Indonesia)
Kenzoflex (Mexico)
Loxan (Ecuador)
Medociprin (Thailand)
Mitroken (Mexico)
Nivoflox (Mexico)
Probiox (Peru)
Proflaxin (Costa-Rica; Nicaragua)
Proflox (Thailand)
Proksi 250 (El-Salvador; Guatemala; Honduras)
Proksi 500 (El-Salvador; Guatemala; Honduras)
Quinolid (El-Salvador; Guatemala; Honduras)
Quintor (India)
Rancif (Indonesia)
Roxytal (Colombia)
Septicide (Peru)
Sophixin Ofteno (Mexico)
Spitacin (Korea)
Superocin (Taiwan)
Unex (Ecuador)
Uniflox (France)
Zumaflox (Indonesia)

COST OF THERAPY: $52.64 (Urinary Infections; Cipro Tablet; 250 mg; 2/day; 7 days)





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