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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (C's) » Clonidine



Clonidine hydrochloride USP is a centrally acting antihypertensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.

The inactive ingredients in Catapres are colloidal silicon dioxide, corn starch, dibasic calcium phosphate, FD&C Yellow No. 6, gelatin, glycerin, lactose, magnesium stearate, methylparaben, propylparaben. The Catapres 0.1 mg tablet also contains FD&C Blue No. 1 and FD&C Red No. 3.

Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-(2,6-dichlorophenylamino)-2- imidazoline hydrochloride. It has the following molecular formula: C9H9CI2N3 · HCl, with molecular weight of 266.56.

Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol.

Epidural Injection


Note: Epidural clonidine is not recommended for obsetrical, post-partum, or peri-operative pain management. The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. However, in a rare obstetrical, post-partum or peri-operative patient, potential benefits may outweigh the possible risks.

Clonidine hydrochloride injection is a centrally-acting analgesic solution for use in continuous epidural infusion devices.

Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical names are Benzenamine, 2, 6-dichloro-N-2-imidazolidinylidene-monohydrochloride and 2-[(2,6-dichlorophenyl)imino]imidazolidine monohydrochloride. Its molecular formula is C9H9CI2N3 · HCl, with molecular weight of 266.56.

Clonidine hydrochloride injection is supplied as a clear, colorless, preservative-free, pyrogen-free, aqueous sterile solution (pH 5 to 7) in a single-dose, 10 ml vial. Each ml of solution contains 100 mcg of clonidine hydrochloride, USP and 9 mg sodium chloride, USP in water for injection, USP. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment. Each 10 ml vial contains 1 mg (1000 mcg) of clonidine hydrochloride.


CATEGORIES: Hypertension; Pregnancy Category C; FDA Approved 1984 Oct; Orphan Drugs

FDA Drug Class: Alpha Blockers; Antihypertensives

BRAND NAMES: Aclon; Arkamin; Cares; Catapres; Clinolou; Clonnirit; Daipres; Dixarit; Drylon; Duraclon; Hyposyn; Ipotensium; Isoglaucon; Josechazu; Normopresan; Sulmidine; Taltecin; Tinya; Winpress
(Foreign brand names outside U.S. in italics)

COST OF THERAPY: $511.00 (Hypertension; Catapres Tablet; 0.1 mg; 2/day; 365 days)

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