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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Dihydroergotamine



DESCRIPTION

D.H.E. 45 (dihydroergotamine mesylate) Injection, USP Rx only

D.H.E. 45® is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. D.H.E. 45® is known chemically as ergotaman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'- (phenylmethyl) (5'a)-, monomethanesulfonate. Its molecular weight is 679. 80 and its empirical formula is C13H37N5O5 · CH4O3S.

D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is a clear, colorless solution supplied in sterile ampuls for I.V., I.M. , or subcutaneous administration containing per mL:

    dihydroergotamine mesylate, USP .................................. 1 mg
    methanesulfonic acid/sodium hydroxide, qs to ..................pH 3.6 ± 0. 4
    alcohol USP ...................................................................6.1 % by vol.
    glycerin, UP ...................................................................15% by wt.
    water for injection, USP , qs to ...................................... 1 ml .




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