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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (D's) » Diphenoxylate / Atropine


Each Lomotil tablet and each 5 ml of Lomotil liquid for oral use contains:

Diphenoxylate Hydrochloride (abbreviated here as HCl: 2.5 mg)

(Warning--May be habit forming.)

Atropine Sulfate: 0.025 mg

Diphenoxylate HCl, an antidiarrheal, is ethyl 1-(3-cyano-3,3- diphenylpropyl)-4-phenylisonipecotate monohydrochloride.

Atropine sulfate, an anticholinergic, is endo-(±)--(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1) oct-3-yl ester sulfate (2:1) (salt) monohydrate.

Inactive ingredients of Lomotil tablets include acacia, corn, starch, magnesium stearate, sorbitol, sucrose, and talc. Inactive ingredients of Lomotil liquid include cherry flavor, citric acid, ethyl alcohol 15%, FD&C Yellow No. 6, glycerin, sodium phosphate, sorbitol, and water.

Important Information

Lomotil is classified as a Schedule V controlled substance by federal law. Diphenoxylate HCl is chemically related to the narcotic meperidine. Therefore, in case of overdosage, treatment is similar to that for meperidine or morphine intoxication, in which prolonged and careful monitoring is essential. Respiratory depression may be evidenced as late as 30 hours after ingestion and may recur in spite of an initial response to narcotic antagonists. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage. LOMOTIL IS NOT AN INNOCUOUS DRUG AND DOSAGE RECOMMENDATIONS SHOULD BE STRICTLY ADHERED TO, ESPECIALLY IN CHILDREN, KEEP THIS AND ALL MEDICATIONS OUT OF REACH OF CHILDREN.


CATEGORIES: Diarrhea; Pregnancy Category C; DEA Class CV; FDA Approval Pre 1982

FDA Drug Class: Antidiarrheals; Cold Remedies; Gastrointestinal, Miscellaneous

BRAND NAMES: Celidin; Dhamotil; Diarase; Diarest; Diarphen; Diarsed; Diastop; Dilomil; Diphenatol; Diphensil; Ditropine; Erlotyl; Katevan; Lomocot; Lomotil; Lonox; Lotab; Protector; Reasac; Reasec; Retardin; Sedistal; Tropatil; Vi-Atro
(Foreign brand names outside U.S. in italics)

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