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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (G's) » Glipizide


Immediate and Extended Release Tablets

Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea class.

The chemical abstracts name of glipizide is 1-cyclohexyl-3-[[p-(2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea. The molecular formula is C21H27N5O4S; the molecular weight is 445.55.

Glipizide is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide.

Immediate Release Tablets: Each immediate release tablet, for oral administration contains glipizide, 5 mg or 10 mg and the following inactive ingredients: corn starch, anhydrous lactose, microcrystalline cellulose, colloidal silicon dioxide and stearic acid.

Extended Release Tablets: Inert ingredients in the formulations are: polyethylene oxide, hydroxypropyl methylcellulose, magnesium stearate, sodium chloride, red ferric oxide, cellulose acetate, polyethylene glycol, opadry white and black ink.

Extended Release Tablets

Glucotrol XL extended release tablets are similar in appearance to a conventional tablet. It consists, however, of an osmotically active drug core surrounded by a semipermeable membrane. The core itself is divided into two layers: an "active" layer containing the drug, and a "push" layer containing pharmacologically insert (but osmotically active) components. The membrane surrounding the tablet is permeable to water but not to drug or osmotic excipients. As water from the gastrointestinal tract enters the tablet pressure increases in the osmotic layer and "pushes" against the drug layer, resulting in the release of through a small, laser-drilled orifice in the membrane on the drug side of the tablet.

The Glucotrol XL extended release tablet is designed to provide a controlled rate of delivery of glipizide. into the gastrointestinal lumen which is independent of pH or gastrointestinal motility. The function of the Glucotrol XL extended release tablet depends upon the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the GI tract. Drug delivery is essentially constant as long as the osmotic gradient remains constant, and then gradually falls to zero. The biologically inert components of the tablet remain intact during drug GI transit and are eliminated in the feces as an insoluble shell.


CATEGORIES: Diabetes mellitus; Pregnancy Category C; FDA Approved 1984 May; Top 200 Drugs

FDA Drug Classes: Blood Glucose Regulators


BRAND NAMES: Aldiab; Digrin; Dipazide; Glibenese; Glibetin; Glican; Glidiab; Glipid; Glucolip; Gluco-Rite; Glucotrol; Glucotrol Xl; Glucozide; Glupitel; Glupizide; Glyde; Glynase; Melizide; Mindiab; Minidab; Minidiab; Minodiab; Napizide; Ozidia; Sucrazide
(Foreign Brand names outside U.S. in italics)

Aldiab (Indonesia)
Digrin (Korea)
Dipazide (Thailand)
Glibenese (Bahrain; Belgium; Benin; Burkina-Faso; Cyprus; Denmark; Egypt; Ethiopia; Finland; France; Gambia; Germany; Ghana; Guinea; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco; Netherlands; Niger; Nigeria; Oman; Qatar; Republic-Of-Yemen; Russia; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Spain; Sudan; Sweden; Switzerland; Syria; Tanzania; Tunia; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Glibetin (Taiwan)
Glican (El-Salvador)
Glidiab (Hong-Kong; Taiwan)
Glipid (New-Zealand)
Glucolip (India)
Gluco-Rite (Israel)
Glucozide (Taiwan)
Glupitel (Mexico)
Glupizide (Taiwan)
Glyde (India)
Glynase (India)
Melizide (Australia; Finland; New-Zealand)
Mindiab (Finland; Hong-Kong; Norway; Russia; Sweden)
Minidiab (Australia; Austria; Bahrain; Belgium; Benin; Bulgaria; Burkina-Faso; Cyprus; Czech-Republic; Denmark; Egypt; Ethiopia; France; Gambia; Ghana; Guinea; Hong-Kong; Hungary; Indonesia; Iran; Iraq; Israel; Italy; Ivory-Coast; Jordan; Kenya; Kuwait; Lebanon; Liberia; Libya; Malawi; Malaysia; Mali; Mauritania; Mauritius; Morocco; New-Zealand; New-Zealand; Niger; Nigeria; Oman; Philippines; Portugal; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Taiwan; Tanzania; Thailand; Tunia; Turkey; Uganda; United-Arab-Emirates; Zambia; Zimbabwe)
Minodiab (Argentina; Costa-Rica; Dominican-Republic; El-Salvador; England; Greece; Honduras; Mexico; Nicaragua; Panama; Spain)
Napizide (Taiwan)
Ozidia (France)
Sucrazide (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)

COST OF THERAPY: $149.65 (Diabetes; Glucotrol Tablet; 5 mg; 1/day; 365 days)

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