ZYVOX I.V. Injection, ZYVOX Tablets, and ZYVOX for Oral Suspension contain
linezolid, which is a synthetic antibacterial agent of the oxazolidinone
class. The chemical name for linezolid is (S)-N-[[3-[3-Fluoro-4-(4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide.
The empirical formula is C16H20FN3O4.
Its molecular weight is 337.35.
ZYVOX I.V.Injection is supplied as a ready-to-use sterile isotonic solution
for intravenous infusion. Each mL contains 2 mg of linezolid. Inactive
ingredients are sodium citrate, citric acid, and dextrose in an aqueous
vehicle for intravenous administration. The sodium (Na+) content
is 0.38 mg/mL (5 mEq per 300-mL bag; 3.3 mEq per 20O-mL bag; and 1.7 mEq
per 100-mL bag).
ZYVOX Tablets for oral administration contain 400 mg or 600 mg linezolid
as film-coated compressed tablets. Inactive ingredients are corn starch,
microcrystalline cellulose, hydroxypropylcellulose, sodium starch glycolate,
magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol,
titanium dioxide, and carnauba wax. The sodium (Na+) content
is 1.95 mg per 400-mg tablet and 2.92 mg per 600-mg tablet (0.1 mEq per
tablet, regardless of strength).
ZYVOX for Oral Suspension is supplied as an orange-flavored granule/powder
for constitution into a suspension for oral administration. Following
constitution, each 5 mL contains 100 mg of linezolid. Inactive ingredients
are sucrose, citric acid, sodium citrate, microcrystalline cellulose and
carboxymethylcellulose sodium, aspartame, xanthan gum, mannitol, sodium
benzoate, colloidal silicon dioxide, sodium chloride, and flavors (see
PATIENT INFORMATION). The sodium
(Na+) content is 8.52 mg per 5 mL (0.4 mEq per 5 mL).