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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Lisinopril



WARNING

Use In Pregnancy: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, lisinopril should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.


DESCRIPTION

Lisinopril is an oral long-acting angiotensin converting enzyme inhibitor. Lisinopril, a synthetic peptide derivative, is chemically described as (S)-1-[N2-(1-Carboxy-3- phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is C21H31N3O52H2O.

Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water and sparingly soluble in methanol and practically insoluble in ethanol.

Zestril is supplied as 2.5 mg, 5 mg, 10 mg, 20 mg and 40 mg tablets for oral administration.

Inactive Ingredients:

2.5 mg Tablets: Calcium phosphate, magnesium stearate, mannitol, starch.
5, 10, and 20 mg Tablets: Calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch.
40 mg Tablets: Calcium phosphate, magnesium stearate, mannitol, starch, yellow ferric oxide.

CATEGORIES, BRAND NAMES

CATEGORIES: Heart failure, congestive; Hypertension, essential; Pregnancy Category D; FDA Approved 1987 Dec; Top 200 Drugs

FDA Drug Classes: Ace Inhibitors; Antihypertensives

BRAND NAMES:

BRAND NAMES: Acerbon; Alapril; Carace; Cipral; Cipril; Coric; Inopril; Linopril; Linvas; Lipril; Lisipril; Lisoril; Lispril; Listril; Noperten; Novatec; Presiten; Prinil; Prinivil; Prinvil; Tensopril; Tensyn; Vivatec; Zestril
(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:
Acerbon (Germany)
Alapril (Italy)
Carace (England)
Cipral (Bahrain; Cyprus; Egypt; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Cipril (India)
Coric (Germany)
Inopril (Bahrain; Cyprus; Egypt; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-of-Yemen; Saudi-Arabia; Syria; United-Arab-Emirates)
Linopril (Colombia)
Linvas (India)
Lipril (India)
Lisipril (Dominican-Republic)
Lisoril (India)
Lispril (Thailand)
Listril (India)
Noperten (Indonesia)
Novatec (Belgium; Netherlands)
Presiten (Dominican-Republic)
Prinil (Switzerland)
Tensopril (Israel)
Tensyn (Colombia)
Vivatec (Denmark; Finland; Norway; Sweden)

COST OF THERAPY: $339.45 (Hypertension; Zestril Tablet; 10 mg; 1/day; 365 days)





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