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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (L's) » Losartan and Hydrochlorothiazide



DESCRIPTION

WARNING: USE IN PREGNANCY: When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angio tensin system can cause injury and even death to the developing fetus. When pregnancy is detected, HYZAAR should be discontinued as soon as possible. (See WARNINGS: Fetal/Neonatal Morbidity and Mortality.)

HYZAAR (losartan potassium-hydrochlorothiazide), combines an angiotensin II receptor (type AT1) antagonist and a diuretic, hydrochlorothiazide. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol monopotassiurn salt. Its empirical formula is C22H22ClKN6O.

Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone.

Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1- dioxide. Its empirical formula is C7H8ClN3O4S2.

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

HYZAAR is available for oral administration containing 50 mg of losartan potassium, 12.5 mg of hydrochlorothiazide and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, titanium dioxide and D&C yellow No. 10 aluminum lake.

HYZAAR contains 4.24 mg (0.108 mEq) of potassium.





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