MIVACRON Ò Injection
This drug should be administered
only by adequately trained individuals familiar with its actions,
characteristics, and hazards.
MIVACRON (mivacurium chloride) is a short-acting, nondepolarizing
skeletal muscle relaxant
(IV) administration. Mivacurium chloride is [R-[R*,R*-(E)]]-2,2´-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]
The molecular formula
and the molecular weight
The partition coefficient
of the compound is
0.015 in a 1-octanol/distilled water system
at 25° C.
is a mixture of three
stereoisomers: (1R, 1´R, 2S, 2´S), the trans-trans diester;
(1R, 1´R, 2R, 2´S), the cis-trans diester; and (1R,
1´R, 2R, 2´R), the cis-cis diester. The trans-trans
and cis-trans stereoisomers comprise 92% to 96% of mivacurium chloride
and their neuromuscular
are not significantly different from each other or from mivacurium
chloride. The cis-cis diester has been estimated from studies in
cats to have one tenth the neuromuscular
of the other two stereoisomers.
MIVACRON Injection is a sterile,
(pH 3.5 to 5.0) containing mivacurium chloride
equivalent to 2 mg/mL
mivacurium in Water for Injection. Hydrochloric acid
may have been added to adjust pH. Multiple-dose vials contain 0.9%
w/v benzyl alcohol.