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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Mivacurium



DESCRIPTION

MIVACRON Ò Injection

This drug should be administered only by adequately trained individuals familiar with its actions, characteristics, and hazards.

MIVACRON (mivacurium chloride) is a short-acting, nondepolarizing skeletal muscle relaxant for intravenous (IV) administration. Mivacurium chloride is [R-[R*,R*-(E)]]-2,2´-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)] bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5- trimethoxyphenyl)methyl]isoquinolinium]dichloride. The molecular formula is C58H80Cl2N2O14 and the molecular weight is 1,100.18.

The partition coefficient of the compound is 0.015 in a 1-octanol/distilled water system at 25° C.

Mivacurium chloride is a mixture of three stereoisomers: (1R, 1´R, 2S, 2´S), the trans-trans diester; (1R, 1´R, 2R, 2´S), the cis-trans diester; and (1R, 1´R, 2R, 2´R), the cis-cis diester. The trans-trans and cis-trans stereoisomers comprise 92% to 96% of mivacurium chloride and their neuromuscular blocking potencies are not significantly different from each other or from mivacurium chloride. The cis-cis diester has been estimated from studies in cats to have one tenth the neuromuscular blocking potency of the other two stereoisomers.

MIVACRON Injection is a sterile, non-pyrogenic solution (pH 3.5 to 5.0) containing mivacurium chloride equivalent to 2 mg/mL mivacurium in Water for Injection. Hydrochloric acid may have been added to adjust pH. Multiple-dose vials contain 0.9% w/v benzyl alcohol.





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