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You are here: Home » eGM Resources » Health Information & Resources Portal|Home » RX Drug List (listed alphabetically) » Drug Reference (M's) » Mometasone Furoate (nasal spray)


NASONEX® (mometasone furoate monohydrate) Nasal Spray, 50 µg*

*calculated on the anhydrous basis

Mometasone furoate monohydrate, the active component of NASONEX Nasal Spray, 50 µg, is an anti- inflammatory corticosteroid having the chemical name, 9,21-Dichloro-11b,17-dihydroxy-16a -methylpregna-1,4-diene-3,20-dione 17-(2-furoate) monohydrate, the following empirical formula C27H30C12O6 H2O and a molecular weight of 539.45.

Mometasone furoate monohydrate is a white powder. It is practically insoluble in water; slightly soluble in methanol, ethanol, and isopropanol; soluble in acetone and chloroform; and freely soluble in tetrahydrofuran. Its partition coefficient between octanol and water is greater than 5000.

NASONEX Nasal Spray, 50 µg is a metered-dose, manual pump spray unit containing an aqueous suspension of mometa- sone furoate monohydrate equivalent to 0.05% w/w mometasone furoate calculated on the anhydrous basis; in an aqueous medium containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, sodium citrate, 0.25% w/w phenylethyl alcohol, citric acid, benzalkonium chloride, and polysorbate 80. The pH is between 4.3 and 4.9.

After initial priming (10 actuations), each actuation of the pump delivers a metered spray containing 100 mg of suspension containing mometasone furoate monohydrate equivalent to 50 µg of mometasone furoate calculated on the anhydrous basis. Each bottle of NASONEX Nasal Spray, 50 µg provides 120 sprays.

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